On 21 August 2010, Messi scored a hat-trick in his first start of the season in a 4–0 victory over Sevilla FC in the Supercopa de España, helping Barcelona secure their first trophy of the season after a 1–3 first leg loss.
On 19 September 2010, Messi suffered an ankle injury due to an ill-advised tackle by Atlético Madrid defender Tomáš Ujfaluši in the 92nd minute of their Round 3 match at the Vicente Calderón Stadium. At first sight it was feared that Messi suffered a broken ankle that could have kept the star player away from the pitch for a minimum of six months, but MRI performed the next day in Barcelona showed he suffered a sprain in the internal and external ligaments of his right ankle. Team-mate David Villa stated "the tackle on Messi was brutal" after watching the video of the play and also added that he believed the Atlético defender "didn't go into the tackle to hurt". The incident caused widespread media attention and brought up the debate of equality in protecting all players in the game.
Against Almería Messi scored his second hat-trick of the season in an impressive 8–0 away win, the second of which was his 100th La Liga goal.
Messi won the 2010 FIFA Ballon d'Or, beating his Barcelona teammates Xavi and Iniesta. Messi had been nominated for the awards for the fourth consecutive year. On 5 February, Barcelona broke the record for most consecutive league wins with 16 victories after they defeated Atlético Madrid 3–0 at the Camp Nou. Lionel Messi scored a hat-trick to ensure the victory for his side and after the match he stated, "it's an honor to be able to pass a record set by a great like Di Stéfano" and "if the record has been around for so long is because it's very complicated to achieve and we have reached it by defeating a very difficult team who's going through a bad situation, which makes it even more difficult."
After failing to score for a month he scored a brace against UD Almería; the second goal was his 47th of the season, equalling his club record return of the previous season. He surpassed his record on 12 April 2011 by scoring the winner against Shakhtar Donetsk in a UEFA Champions League game, which put him in the record book as all time top scorer in a single season for Barcelona. He scored his eighth goal on El Clásico on a 1–1 tie at the Santiago Bernabéu Stadium. On 23 April, Messi scored his 50th goal of the season against CA Osasuna in a 2–0 home victory which he came on as a substitute in the 60th minute. He finished the season by winning La Liga and scoring 31 goals as he finished runner-up in the Pichichi trophy to Cristiano Ronaldo, who had managed to score 40. Messi finished the league season as the top assist provider with 18 assists.
On 20 April, Barcelona were defeated by arch-rivals Real Madrid in the 2011 Copa del Rey Final. Messi set up a goal for Pedro, which was however ruled offside. Cristiano Ronaldo scored the only goal of the match in extra time. Messi was however the joint top-scorer of the tournament along with Cristiano Ronaldo, with 7 goals.
In the first leg of the Champions League semi-finals, he gave a memorable performance, scoring twice against Real Madrid in a 2–0 win, the second goal (a dribble past several players) being acclaimed as one of the best ever at that stage of the competition. At the Champions League Final at Wembley, Messi scored the eventual game-clinching goal to give Barcelona their third title in six years and fourth overall. This was also Messi's 12th goal in the Champions League that season, which allowed him to tie Ruud Van Nistelrooy's record of 12 goals in a single European Cup season, after it was re-established as the UEFA Champions League, in 1992. The overall record of goals scored in a single European Cup Season, is José Altafini's record of 14 goals, which Messi did however equal in the following season. Messi finished the 2010-11 season with 53 goals and 24 assists in all competitions combined.
