For the 2010 World Cup, Messi wore the number 10 shirt for the first time in a major tournament. Messi played the entire game on Argentina's opening match in the 2010 World Cup, the 1–0 victory against Nigeria. He had several opportunities to score but was repeatedly denied by Vincent Enyeama. Messi started in Argentina's following 4–1 win against Korea Republic; he played in more of an attacking midfielder and playmaking role under Maradona, and participated in all of the goals of his team, helping Gonzalo Higuaín score a hat-trick. On the third and last group stage match Messi captained during Argentina's 2–0 win over Greece, again being the centrepoint of Argentina's play and was voted man of the match.
At the Round of 16 he assisted Carlos Tévez for the first goal in a 3–1 win against Mexico. The World Cup ended for Argentina with a 4–0 loss against Germany in the quarter-finals.